777. Ten Year Experience of Tertiary Hospital Regarding Epidemiology, Diagnostic Method, and Drug Resistance of Tuberculosis - Jeddah , Saudi Arabia
Session: Poster Abstract Session: Tuberculosis and Other Mycobacterial Infections
Thursday, October 4, 2018
Room: S Poster Hall
Posters
  • TB-Poster-IDWeek-2018-Final.pdf (323.7 kB)
  • Ten Year Experience Of Tertiary Hospital Regarding Epidemiology, Diagnostic Method, And Drug Resistance Of Tuberculosis - Jeddah , Saudi Arabia 

    Mohammad Qutub, Ph.D1 , Yasser Aldabbagh 2 , Prasanth Govindan3, Ebtihal Alamoudi4

    1.Senior Clinical Microbiology Scientist, King Faisal Specialist Hospital And Research Center, Jeddah, Saudi Arabia

    2.Internal Medicine Resident, Dr Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

    3.Mediacl Technologist, King Faisal Specialist Hospital And Research Center, Jeddah, Saudi Arabia

    4.Clinical Microbiologist, Dr Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

    Background: The prevalence of tuberculosis across Saudi Arabia is variable with western provinces have the highest incidence. This study aimed to determine the epidemiology of tuberculosis in Jeddah, the age and gender distribution and the accuracy of conventional diagnostic method, for better understanding of tuberculosis resistant pattern in the country.  Methods: 344 culture proven tuberculosis where collected from November 2006 to November 2016 in KFSHRC.  AFB smear, and nucleic acid amplification test (NAAT) was conducted in all positive cultures and all data were analyzed using SPSS. Mean days number to culture positivity was 12.79. Results: TB showed young age predominant (59.5%) compared to older population (37.0%) and pediatrics (3.5%), with 55.4 % males and 44.6 % females, 54.8 % of samples were taken from pulmonary and 45.2 % from extra pulmonary site of infection. 68.3 % and 5.9 % of the tuberculosis proven culture were negative by using AFB smear and NAAT respectively, and only 68.8 % were positive for mycobacterium tuberculosis complex by using NAAT. Resistant level to first line anti tuberculosis of 12.5% , 10.3 % , 5.2 % , 2.6 % , 1.3 % , 2.6 % to  Streptomycin , isoniazid , pyrazinamide ,  Rifampicin , Ethambutol and multidrug resistant respectively was observed in our study. Conclusion: Young age predominance , high values of negative smear and NAAT , increased incidence of extra pulmonary site of infection and Re-emergence of tuberculosis resistant which  was observed in our study compared to previous national surveys (Illustrated in Figure 1) , all should alter physicians’ Attention  when investigating patients in Saudi Arabia and high clinical suspicion should be considered .

    Mohammed Qutub, PhD1, Yasser Aldabbagh, Internal Medicine Resident2, Prasanth Govindan, PhD3 and Ebtihal Alamoudi, Medical Student2, (1)Pathology-Microbiology, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia, (2)Dr Soliman Fakeeh Hospital, Jeddah, Saudi Arabia, (3)King Faisal Specialist Hospital and Research Centre-Jeddah Branch, Jeddah, Saudi Arabia

    Disclosures:

    M. Qutub, None

    Y. Aldabbagh, None

    P. Govindan, None

    E. Alamoudi, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.