2521. The Potential Rise in the Incidence of Rotavirus G3P[8] in Kuwait.
Session: Poster Abstract Session: Virology Potpourri
Saturday, October 6, 2018
Room: S Poster Hall
Posters
  • Rotavirus G3P8 poster IDWeek 2018.pdf (1.1 MB)
  • Background:

    The group A rotavirus infections are associated with severe gastroenteritis in children. G1P[8] was the most prevalent genotype found in Kuwait in a study conducted between 2005 and 2006. The demographic change in Kuwait, and the recent decision to include the Rotateq vaccine in the Kuwait national immunization program, prompted us to investigate a potential change in the prevalence of rotavirus genotypes circulating in Kuwait, and to identify the VP4 and VP7 subgenomic lineages.

    Methods:

    Viral RNA was isolated from the stool samples of 101 children under 5 years of age, hospitalized for severe diarrhea. Rotavirus dsRNA was detected by RT-PCR in 24.7% of children with median age of 1 year.

    Results:

    The genotype G3P[8] accounted for 47% of cases, followed by G1P[8] (26%), G9P[8] (10.5%), G4P[8] (10.5%), and G9P[4] (5%). Only VP7 nucleotide sequences of rotavirus G3 or G4 type clustered in the same lineage as RotaTeq, while most VP4 nucleotide sequences of rotavirus P[8] type clustered in a different lineage than Rotarix and RotaTeq vaccines.

    Conclusion: Our findings highlight the potential rise in the incidence of rotavirus G3P[8] in Kuwait, and invites future investigations to know whether the recent introduction of RotaTeq vaccine selects for certain genotypes and subgenomic lineages.

    Widad Widad Al-Nakib, FRCPath., FIDSA, Microbiology, Faculty of Medicine, Kuwait University, Kuwait, Kuwait and Wassim Chehadeh, PhD, Virology Unit, Faculty of Medicine, Kuwait, Kuwait

    Disclosures:

    W. Widad Al-Nakib, None

    W. Chehadeh, None

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