764. Impact of Diabetes Mellitus on the Presentation and Response to Treatment of Adults with Pulmonary Tuberculosis in Qatar
Session: Poster Abstract Session: Tuberculosis and Other Mycobacterial Infections
Thursday, October 4, 2018
Room: S Poster Hall
Background: Persons with diabetes mellitus (DM) have a three-fold increased risk of TB. Vitamin D deficiency also is associated with a four-fold increase in risk of progression of TB from latent TB infection to active TB. Qatar is an oil rich country with high prevalence of diabetes, obesity and vitamin D deficiency. We aimed to evaluate the effect of diabetes mellitus on manifestations and response to treatment in adults with DM and TB.

Methods: Retrospective national hospital-based study of adult from January 2007 to December 2011, comparing TB infected patients with and without DM.

Results: Of 134 adults with DM and TB, 62 (47%) became culture negative after 8 weeks of anti-TB treatment compared to 84 (72%) patients without DM. Patients with DM had more frequent lower lobe disease (28% vs 17%, P = 0.03). Week 8 sputum culture conversion did not differ between patients by the degree of dysglyemia at time of diagnosis and onset of anti-TB treatment (70% vs 46%, P=0.09).

Conclusion: Diabetes mellitus was associated with delayed sputum culture conversion at two month and atypical radiological findings in adults with pulmonary TB in Qatar. Glycemic control had no effect on week-eight sputum culture conversion.

Khalid M. Dousa, FACP, FIDSA, CABIM, Infectious Disease, Case Western Reserve University, Cleveland, OH, Abdelrahman Hamad, MD, Internal Medicine, Hamad General Hospital, Doha, Qatar, Hussam Alsoub, Senior Consultant, Infectious Disease, Hamad Medical Corporation, Doha, Qatar, Abdel-Naser Elzouki, MD, Hamad Medical Center, Doha, Qatar, Mahmoud I. Alwakeel, MD, Emergency Medicine, Hamad Medical Center, Doha, Qatar, Bonnie A. Thiel, M.S., Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH and John L. Johnson, M.D., Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH

Disclosures:

K. M. Dousa, None

A. Hamad, None

H. Alsoub, None

A. N. Elzouki, None

M. I. Alwakeel, None

B. A. Thiel, None

J. L. Johnson, None

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