57. Fatal Mucormycosis: Clinical-Pathologic Correlation Study of Autopsies. Hospital Universitario de Santander (Hus)-Universidad Industrial de Santander (Uis) 2005-2017
Session: Posters in the Park: Posters in the Park
Wednesday, October 3, 2018: 5:30 PM
Room: N Hall D Opening Reception and Posters in the Park Area
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  • Background: Mucormycosis is an acute infection disease caused by a zygomycetes fungus in the Mucorales family. It is particularly noticed in immunocompromised and diabetes mellitus (DM) patients1. The pulmonary and rhinocerebral forms are the most common clinical presentation (CP) of this infection2.

    Methods: An observational, descriptive and retrospective study reports of autopsies between January 2005 and December 2017 from UIS-Pathology service linked to HUS. A correlation between final diagnosis of mucormycosis and pathological results were performed.

    Results: We reviewed 3852 autopsy reports. There were found 19 cases of mucormycosis (0.49% of prevalence), 11 men (M, 58%) and 8 women (F, 42%), :35.31 years. The main associated condition was DM: 6 cases (31.57%); followed by neoplasia and premature babies 2 (10.52%) cases each. The pulmonary presentation was the most common 11 (58%), and the lung as frequently affected organ (15 cases, 79%). The demographic characteristics and other clinicopathological findings are described on the table 1.

    N

    SEX

    AGE

    CP

    TO

    DM

    N

    PR

    INF

    E

    INM

    R

    P

    D

    Mi

    L

    CNS

    GI

    C

    VIH

    FAR

    1

    M

    46

    X

    X

    X

    2

    F

    0

    X

    X

    X

    3

    M

    32

    X

    X

    X

    4

    M

    53

    X

    X

    X

    5

    M

    37

    X

    X

    X

    6

    F

    22

    X

    X

    X

    X

    X

    7

    M

    43

    X

    X

    X

    8

    F

    66

    X

    X

    X

    9

    M

    39

    X

    X

    X

    X

    X

    10

    F

    59

    X

    X

    X

    11

    M

    58

    X

    X

    X

    12

    F

    28

    X

    X

    X

    X

    13

    F

    3

    X

    X

    X

    14

    M

    7

    X

    X

    X

    15

    M

    0

    X

    X

    X

    16

    M

    15

    X

    X

    X

    17

    M

    50

    X

    X

    X

    18

    F

    77

    X

    X

    X

    19

    F

    36

    X

    X

    X

    6

    2

    2

    3

    1

    3

    2

    2

    11

    5

    1

    15

    3

    4

    2

    Table 1. Demographic and clinicopathological findings from the mucormycosis cases. TO: target organ, N:Neoplasia, PR: Premature, Inf: Infection, E: Pregnancy, Inm: Immunodeficiency, Far: Farmacology, R: Rhinocerebral, P: Pulmonar, D: Disseminate, Mi:Miscellany, L:Lung, GI: gastrointestinal C: Cardiac

    Conclusion: Mucormycosis is characterised as an unusual, difficult diagnosis and rapidly changing infection. It has frequently fatal outcome. Patients with decompensated DM and immune system disorders are predominantly infected. Different CP of mucormycosis affects diverse organs. However, the pulmonary system and lungs are the most compromised of all.

    1. Silva P, Avilés CL. Mucormicosis pulmonar. Rev Chil Infect 2004; 21 (1): 61-64
    2. Cox G, Kauffman C, Thorner A (2011) Mucormycosis (zygomycosis). www.uptodate.com. Accessed February 2018.
    María Villada, Medical student1, Elizabeth Mendoza, Medical student1 and Julio César Mantilla Hernández, MD2, (1)Universidad Industrial de Santander, Bucaramanga, Colombia, (2)Department of Pathology, Universidad Industrial de Santander, Bucaramanga, Colombia

    Disclosures:

    M. Villada, None

    E. Mendoza, None

    J. C. Mantilla Hernández, None

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