2356. Neurological Disorders and Radiological Findings. How Are They Related in Congenital Zika Syndrome?
Session: Poster Abstract Session: Pediatric Viral Infections
Saturday, October 6, 2018
Room: S Poster Hall
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  • Background: Although Zika virus (ZIKV) infection causes a broad spectrum of congenital neurological disorders, radiographic
    correlates of clinical outcome are lacking. During 2015-2016 ZIKV outbreak we faced a high incidence of
    microcephaly (MCP) in Rio Grande do Norte State (RN), located in northeast of Brazil. Among all regions, the
    northeast was the most affected by ZIKV. We aimed to identify distinct CT brain scan findings associated with congenital ZIKV infection and correlate them with neuro-clinical disorders in babies with MCP. Their mothers had exanthematous diseases (ED) compatible with ZIKV infection during their pregnancy.

    Methods: Medical evaluation was performed on 38 babies with MCP, up to 17 months old, followed at a center for child
    rehabilitation in RN. All subjects underwent CT brain scan. Cohort enrollment occurred with subjects born
    between January 2015 and May 2016.

    Results: 38 babies with MCP underwent head CT. 68.5% were male, 31.5% were female. The main clinical presentations
    were spasticity, irritability and seizure. On CT, all subjects had brain volume reduction. Intracranial calcification
    (IC) was observed in all of the subjects who presented with irritability and seizures (n = 27) and in 83.3% of
    subjects with spasticity. Lissencephaly was seen in 80% of subjects with irritability, 75% of subjects with seizures
    and 50% with spasticity. Ventricular dilatation was seen in 19 subjects, all of whom had spasticity, 60% who
    presented with irritability and 50% who presented with seizures.

    Conclusion: These new data from a relatively large study, demonstrate that neuroradiographical findings are associated with
    clinical syndromes in affected neonates. IC was the most prevalent CT scan finding (after reduction in the brain
    volume). It seems to be the most common radiological finding related to neuro-clinical disorders in ZIKV infection.
    This study may be used to better describe the congenital Zika syndrome, its clinical/radiological outcomes and
    natural history.

    Nilson N. Mendes Neto, MD, Extension Center, University of California, Davis, Davis, CA; Family Medicine, HUOL, Natal - RN, Brazil, Jessika Maia, MD, HUOL, Natal - RN, Brazil, Marcelo Rodrigues Zacarkim, MD, MS, Harvard Medical School, Boston, MA, Kalyana E. Fernandes, MD, CRI - RN, Natal, Brazil, Igor Thiago Queiroz, MD, PhD, Universidade Potiguar, natal, Brazil, David Aronoff, MD, FIDSA, Medicine, Vanderbilt University School of Medicine, Division of Infectious Diseases, Nashville, TN, A. Desiree Labeaud, MD, MS, Pediatric Infectious Diseases, Stanford University, Stanford, CA and Tabata De Alcantara, MD, MS, CRI-RN, Natal, Brazil


    N. N. Mendes Neto, None

    J. Maia, None

    M. Rodrigues Zacarkim, None

    K. E. Fernandes, None

    I. Thiago Queiroz, None

    D. Aronoff, None

    A. Desiree Labeaud, None

    T. De Alcantara, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.