Poster Abstract Session: Resistance Mechanisms: Gram-Negative
Thursday, October 4, 2018
Room: S Poster Hall
resistance (AMR) is a serious threat to global health with local implications.
AMR varies regionally; however, limited tools are available to aid
practitioners in appropriate antibiotic selection based on statewide
antimicrobial susceptibilities. The objective of this study was to map E.
coli antibiotic susceptibility regionally and longitudinally in Wisconsin.
Methods: Antibiograms from 2009, 2013, and 2015 were collected from health systems,
hospitals, and clinics in Wisconsin, resulting in 218 antibiograms representing
201,091 gram-negative isolates. E. coli antibiotic susceptibility
percentages were weighted by number of isolates and aggregated by county per
interpolation methods (Inverse Distance Weighted, Kriging) were tested by both
county center points and facility geocode where available. Susceptibility data
for clinically relevant urinary tract infection antibiotics were interpolated
to create geographic visualizations of AMR in Wisconsin. Antibiotics included
amoxicillin, trimethoprim/sulfamethoxazole, ciprofloxacin, nitrofurantoin,
ampicillin, ampicillin/sulbactam, levofloxacin. The interpolation extends to
the furthest health system point in each direction and is presented within
state boundaries. Facility geocodes were masked from public display for
confidentiality. City names were added for orientation. The mapping depicts
regional differences, such as 2015 ampicillin susceptibilities ranging 55% to
64% (Figure 1). The maps provide a preliminary susceptibility prediction in
areas where no AMR data were available. Average susceptibilities were compared
across 2009, 2013, and 2015 to map areas with the highest rates of AMR change.
described mapping provides a novel visualization of AMR across Wisconsin. The
maps created will be utilized in continued efforts to improve the functionality
of AMR data in clinical practice to optimize antimicrobial choice.