2509. High-risk human papillomavirus infection and the risk of cardiovascular disease: a cohort study
Session: Poster Abstract Session: Virology Potpourri
Saturday, October 6, 2018
Room: S Poster Hall
  • Poster ID week 2018-09-26 (최종본).jpg (886.0 kB)
  • Background: A study using National Health and Nutrition Examination Survey (NHANES) 2003 to 2006 demonstrated the association between high risk (oncogenic) human papillomavirus (HPV) and an increased prevalence of the self-reported cardiovascular diseases (CVD). However, this study was limited by temporal ambiguity between HPV and CVD, because of its cross-sectional design. We investigated the longitudinal effect of HPV infection on the development of CVD events in a cohort study of Korean women free of CVD at baseline.

    Methods: We conducted a cohort study of 63,411 women aged 30 or older without CVD at baseline who underwent a high-risk HPV test and were followed annually or biennially from 2011 to 2016 for new-onset CVD. CVD was ascertained through the linkage to the Health Insurance and Review Agency database. A Cox-proportional hazards regression model was used to estimate adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) of incident CVD.

    Results: The prevalence of high-risk HPV infection was 7.6%. During 261,598.9 person-years of follow-up, 1,122 cases of new-onset CVD were identified (incidence rate of 4.3 per 103 person-years). The age-adjusted HR (95% CI) comparing high-risk HPV-positive- to high-risk HPV-negative participants was 1.26 (1.03-1.53). After further adjustment for possible confounders, a significant association between high-risk HPV infection and incident CVD was still observed, with a corresponding HR (95% CI) of 1.25 (1.03-1.53). This association was stronger in obese (BMI ≥25 kg/m2) compared to non-obese individuals (BMI <25 kg/m2). Otherwise, the associations between high-risk HPV infection and incident CVD did not differ by various clinically relevant subgroups.

    Conclusion: In this large cohort of apparently healthy young and middle-aged women, high-risk HPV infection was significantly associated with an increased risk of developing CVD, indicating a possible role for high-risk HPV in the pathogenesis of CVD.

    Eun-Jeong Joo, MD, PhD, Division of Infectious Diseases, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), Jungok Kim, MD, PhD, Chungnam National University Hospital, Daejeon, Korea, Republic of (South), So Yeon Park, MD, PhD, Infectious Diseases, Kangdong Sacred Heart Hospital Hallym University School of Medicine, Seoul, Korea, Republic of (South) and Hae Suk Cheong, MD, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South)


    E. J. Joo, None

    J. Kim, None

    S. Y. Park, None

    H. S. Cheong, None

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