2145. Etiology, Incidence and Risk Factors for Meningitis after Craniotomy
Session: Poster Abstract Session: Healthcare Epidemiology: Surgical Site Infections
Saturday, October 6, 2018
Room: S Poster Hall
  • ID_Week_Meningitis.pdf (623.9 kB)
  • Background:

    Meningitis after craniotomy can be devastating. The objective of our study is to answer four questions: a) what is the risk of meningitis after craniotomy? b) What are the main microorganisms causing meningitis after craniotomy? c) What is the impact of meningitis in the hospital length of stay and mortality? d) What are risk factors for meningitis after craniotomy?


    Surveillance data based on NHSN/CDC protocols were collected between 2013 and 2017 from nine hospitals at Belo Horizonte, Brazil. Outcome: meningitis, hospital death and total length of hospital stay. 23 independent variables were analyzed using Epi Info and applying statistical two-tailed test hypothesis with significance level of 5%.


    A sample of 4,549 patients submitted to craniotomy was analyzed: risk of meningitis = 1.9% (I.C. 95% = 1.6%; 2.4%). Mortality rate in patients without infection was 9% rising to 33% in infected patients (p<0.01). Hospital length of stay in non-infected patients (days): mean = 18, median = 7, std. dev. = 36. Hospital stay in infected patients: mean = 56, median = 37, std. dev. = 63 (p<0.001). The duration of procedure was the main risk factor for meningitis: 1.5% risk of meningitis in surgery less than or equal to 4 hours versus 2.5% if the duration of procedure was more than 4 hours (Relative Risk = 1.7; p = 0.041). From 88 meningitis, in 68 (77%) the etiologic agent was identified: Klebsiella pneumoniae (20%), Staphylococcus aureus (16%), Acinetobacter baumannii (13%), Pseudomonas aeruginosa (9%), Staphylococcus sp (8%), Acinetobacter sp (7%), Staphylococcus epidermidis (5%), and other (20%).


    The study showed how much meningitis is devastating, rising the death risk and length of hospital stay.

    Handerson Dias Duarte De Carvalho, Medical Student1, Lucca Gontijo Giarola, Medical Student2, Gregory Lauar E Souza, Medical Student3, Gilberto Diniz, MD4, Cristóvão De Deus Martins Oliveira, Medical Student3, Estevão Silva, MD5, Edna Leite, MD6, Bráulio Couto, PhD2 and Carlos Starling, Md.7, (1)Centro Universitario de Belo Horizonte, Belo Horizonte, Brazil, (2)Centro Universitário de Belo Horizonte - UniBH, Belo Horizonte, Brazil, (3)Faculdade de Medicina do Centro Universitário de Belo Horizonte, Belo Horizonte, Brazil, (4)HUAV - Hospital Universitطrio Alzira Velano. Unifenas, Alfenas, Brazil, (5)Hospital Madre Teresa e Instituto Biocor, Belo Horizonte, Brazil, (6)Hospital Risoleta Tolentino Neves, Belo Horizonte, Brazil, (7)Hospital Lifecenter, Belo Horizonte, Brazil


    H. Dias Duarte De Carvalho, None

    L. Gontijo Giarola, None

    G. Lauar E Souza, None

    G. Diniz, None

    C. De Deus Martins Oliveira, None

    E. Silva, None

    E. Leite, None

    B. Couto, None

    C. Starling, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.