1228. Incidence of Staphylococcus aureus Infection after Elective Surgeries among Adults in U.S. Hospitals
Session: Poster Abstract Session: Healthcare Epidemiology: MSSA, MRSA and Other Gram Positive Infections
Friday, October 5, 2018
Room: S Poster Hall
  • 1288_IDWPoster2018_JDreyfus_12Sept2018 FINAL v2.pdf (427.9 kB)
  • Background: S. aureus (SA) is a leading cause of postsurgical infections. National estimates of these infections after elective surgeries based on microbiology data are limited. This study assessed 180-day postsurgical SA incidence in real-world hospital settings.

    Methods: Adults (≥18 years) who underwent elective surgery during a hospital-based outpatient or inpatient encounter from 7/1/2010–6/30/2015 at one of 181 hospitals reporting microbiology results in the Premier Healthcare Database (PHD). Eighty-seven surgical categories were defined using ICD-9-CM and CPT procedure codes according to National Hospital Surveillance Network groupings plus additional categories. Microbiology results and ICD-9-CM diagnosis codes were used to identify invasive (eg, deep incisional and organ-space SSI, bloodstream) and overall (ie, invasive, superficial incisional, urinary tract, respiratory) SA infections. Cumulative 180-day SA infection rates were calculated as number of infections divided by number of discharges with elective surgeries. National infection volumes were calculated by multiplying infection rates by national inpatient elective surgery estimates using surgery counts in the entire PHD (665 hospitals) and weights based on hospital characteristics.

    Results: Following 1,116,994 hospital-based outpatient elective surgeries, 180-day SA incidence was 1.19% overall, with 0.38% complicated by invasive SA infections. Among 884,803 inpatient elective surgeries, overall and invasive 180-day SA infection incidence was 1.35% and 0.53%, respectively. This translated to an estimated 57,200 SA infections (22,400 invasive) among an estimated 4.2 million elective inpatient surgeries annually in the U.S. Methicillin-resistance (MRSA) was observed in 45% and 46% of SA infections after inpatient and outpatient surgeries, respectively.  Figure 1 shows cumulative SA incidence rates at each time point after outpatient and inpatient elective surgeries.  Figure 2 delineates the incidence rates for each type of SA infection.

    Conclusion: Our study indicated similar SA infection rates after inpatient and outpatient elective surgeries.  The results highlight the much larger burden of disease of SA infection in the U.S. beyond inpatient surgeries.

    Jill Dreyfus, PhD, MPH, Premier Applied Sciences, Premier, Inc, Stillwater, MN, Elizabeth Begier, MD, MPH, Pfizer, Inc, Pearl River, NY, Holly Yu, MSPH, Pfizer, Inc., Collegeville, PA, Alvaro Quintana, MD, WW Medicines Development & Scientific Affairs, Pfizer Inc., Collegeville, PA, Julie Gayle, MPH, Premier, Inc, Charlotte, NC and Margaret A. Olsen, PhD, MPH, Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO


    J. Dreyfus, Premier, Inc: Employee and Shareholder , Salary .

    E. Begier, Pfizer, Inc: Employee and Shareholder , Salary .

    H. Yu, Pfizer, Inc: Employee and Shareholder , Salary .

    A. Quintana, Pfizer, Inc: Employee and Shareholder , Salary .

    J. Gayle, Premier, Inc: Employee , Salary .

    M. A. Olsen, Pfizer: Consultant , Consulting fee .

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