1854. Effective Antimicrobial Stewardship for Outpatient Parenteral Antimicrobial Therapy (OPAT): Nationwide Experience in Infectious Disease Physician Infusion Centers
Session: Poster Abstract Session: Antimicrobial Stewardship: Outpatient Settings
Saturday, October 6, 2018
Room: S Poster Hall
  • IDWeek 2018_Nathan et al_#1854_ASP for OPAT.pdf (425.3 kB)
  • Background: Antimicrobial stewardship (AS) is an important factor in combatting antimicrobial resistance and optimizing clinical outcomes, especially in the outpatient setting. With no AS guidelines in the US for OPAT, we developed an antimicrobial stewardship program (ASP) for OPAT in 2016, which was piloted and applied to Infectious Disease practices and infusion centers.  The program was expanded and assessed nationally in additional centers in 2017, adding appropriateness of empiric therapy (tx), supervision of first doses of antimicrobials, compliance with tx regimen, appropriate tx changes and staff education.

    Methods:  An assessment instrument was developed through literature review, expert opinion and validated with a logistic model.  Patients (pts) receiving OPAT in 2017 were randomly selected and retrospectively reviewed based on annual pt volume from 14 OPAT practices. The table shows the ASP assessment tool consisting of 7 Core Elements (CE) scored at 10 points each and 6 Other Elements (OE) scored at 5 points each. Logistic regression was used to validate the relationship between the composite outcome elements and all other elements (aOR=0.929, p=0.0005, c=0.704). Appropriateness of empiric tx and tx length was evaluated using evidence-based guidelines. Each pt OPAT course was assessed and scored for compliance to required elements with an achievable score per pt of 100 points (100%). IV to PO conversion was evaluated secondarily. Descriptive statistics were used.

    Results:  A total of 200 OPAT courses were scored for compliance to each ASP element as noted in the table. The overall compliance rate for CE and OE was 93.0% and 93.3%, respectively. All CEs were ≥90% compliant, except for duration of tx. This exceeded guidelines in 15% of pt courses due to severe disease presentation.  For the OEs, all achieved ≥90% compliance except labs performed as ordered. Early conversion from IV to PO resulted in a reduction of 240 IV days for 1.2 days per pt.

    Conclusion:  We successfully developed an OPAT ASP with national expansion.  Opportunities were identified for improvement in laboratory processes and enhanced evaluation regarding tx durations. This validated ASP provides a valuable tool for OPAT, incorporating key elements for stewardship success.


    Ramesh V. Nathan, MD, FIDSA1, Richard L. Hengel, MD2, Andrew H. Krinsky, MD3, Thomas K. Sleweon, MD4, Alfred E. Bacon III, MD5, K. Dale Hooker, PharmD6, Claudia P. Schroeder, PharmD, PhD6, Kimberly A. Couch, PharmD, MA, FIDSA, FASHP6 and Lucinda J. Van Anglen, PharmD6, (1)Mazur, Statner, Dutta, Nathan, PC, Thousand Oaks, CA, (2)Atlanta ID Group, Atlanta, GA, (3)Infectious Diseases Associates, Sarasota, FL, (4)ID Specialists of Indiana, Highland, IN, (5)Infectious Disease Associates, PA, Newark, DE, (6)Healix Infusion Therapy, Sugar Land, TX


    R. V. Nathan, Merck & Co.: Scientific Advisor and Speaker's Bureau , Consulting fee and Speaker honorarium . The Medicines Company: Speaker's Bureau , Speaker honorarium . Allergan: Speaker's Bureau , Speaker honorarium .

    R. L. Hengel, Merck & Co.: Scientific Advisor , Consulting fee .

    A. H. Krinsky, None

    T. K. Sleweon, None

    A. E. Bacon III, None

    K. D. Hooker, None

    C. P. Schroeder, None

    K. A. Couch, Allergan: Speaker's Bureau , Speaker honorarium . Merck: Speaker's Bureau , Speaker honorarium . Melinta: Speaker's Bureau , Speaker honorarium .

    L. J. Van Anglen, Merck & Co.: Grant Investigator , Research grant .

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.