597. Pharmacist-led interventions for inpatient HIV-related medication errors
Session: Poster Abstract Session: HIV: Management and Clinical Outcomes
Thursday, October 4, 2018
Room: S Poster Hall
  • IDWeek HIV Poster_FINAL.pdf (598.9 kB)
  • Background: Inpatient HIV-related medication errors occur in up to 86% of patients. The purpose of this study was to evaluate the number of antiretroviral therapy (ART)- and opportunistic infection (OI)-related medication errors following the implementation of pharmacist-directed interventions.

    Methods: This quasi-experiment assessed adult patients with HIV who received ART, OI prophylaxis, or both from 12/1/14-2/28/17 (pre-intervention) or 12/1/17-2/28/18 (post-intervention). Pre-intervention patients were assessed retrospectively, verbal and written education were provided, then prospective audit and feedback was conducted for post-intervention patients. The primary outcome was rate of ART-related medication errors in the pre- versus post-intervention groups. Secondary outcomes included time to resolution of ART- and OI-related medication errors, OI-related medication errors, types of errors, rate of acceptance of recommendations, in-hospital mortality, length of stay, and 30-day readmission.

    Results: Sixty-seven patients were included in each group (pre- and post-intervention). ART errors occurred in 44.8% and 32.8% (p = 0.156), respectively. OI prophylaxis errors occurred in 11.9% vs. 9% (p = 0.572), respectively. No difference was found in types of errors between groups, except medication omission decreased significantly in the post-intervention group (31.3% vs. 11.9%; p = 0.006). The number of pharmacist-based interventions increased in the post-intervention group (6.3% vs. 52.9%; p = 0.001). No statistical difference was found in average time to error resolution (72 vs. 48 hours; p = 0.123), but errors resolved during admission significantly increased (50% vs. 86.8%; p <0.001). No difference was found in rate of intervention acceptance, which was high in both groups.

    Conclusion: In this quasi-experiment, ART and OI prophylaxis medication errors were numerically reduced in the pharmacist-led intervention period, and medication errors were resolved a day faster in the post-intervention period. Future interventions targeting prescribing errors upon admission include follow-up education and evaluation of medication reconciliation practices in HIV-infected patients.

    Mary Joyce B. Wingler, PharmD1, Kayla R. Stover, PharmD, BCPS1,2, Katie E. Barber, PharmD2 and Jamie L. Wagner, PharmD2, (1)University of Mississippi Medical Center, Jackson, MS, (2)University of Mississippi School of Pharmacy, Jackson, MS


    M. J. B. Wingler, None

    K. R. Stover, None

    K. E. Barber, None

    J. L. Wagner, None

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