Methods: All PAF audits on antibiotic and antifungal medications for patients admitted to Lucile Packard Children's Hospital Stanford between 4/18/2017 and 4/17/2018 were included. The PAF program included all pediatric units and injectable antimicrobials active for > 48 hours. PAF documentation was completed in the electronic health record and included the presence or absence of positive microbiologic culture data. Our primary outcome was a comparison of PAF recommendation rate based on the presence or absence of positive culture data. We also evaluated whether there were differences in the recommendation acceptance rate and the type of recommendation based on the presence or absence of positive culture data.
Results: Of the 3,250 audits performed during the study period, 802 (25%) had positive cultures at the time of audit documentation. Of the 802 audits with positive cultures, 299 resulted in a recommendation compared to 824 of the 2,448 audits without positive cultures (37% vs 34%, P = 0.07). PAF recommendations were more likely to be followed when positive culture data was present at the time of audit (80% vs 73%, P = 0.03). The most common recommendation in the presence of positive culture data was to change the antimicrobial (27%) while the most common recommendation in the absence of positive culture data was to stop the antimicrobial (30%).
Conclusion: The presence of positive microbiologic culture data did not impact the PAF recommendation rate. However, recommendations were more likely to be followed when there was concurrent positive culture data. This highlights the importance of obtaining culture data to direct antimicrobial therapy.
H. Schwenk, None
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