Methods: This study was performed at a tertiary-care educational university hospital. Adult (>18 years old) patients with culture proven candidemias in the services or intensive care units of General Surgery Deparment were included in the study between the years of 2012-2017, retrospectively.
Results: A total number of 50 candidemic patients were included. Mean age was 58.96 years and 54% of the patients were female. Forty-four patients had receiving total parenteral nutrition, nine patients had organ transplantation (4 liver and 5 renal transplanted), six patients had intestinal perforation, four patients had intraabdominal abscess and three patients had anastomotic failure. Pathogens were C.albicans (36%; 18/50), C.tropicalis (14%; 7/50), C.glabrata (12%; 6/50), C.parapsilosis (8%; 4/50), C.kefyr (6%; 3/50), C.krusei (4%; 2/50), C. pulcherrima (2%; 1/50), C.neoformans (2%, 1/50), Geotrichum capitatum (2%, 1/50), Candida spp (unidentified, 14%; 7/50), respectively. The highest antifungal sensitivity rates (>90%) were spotted for amphotericin B, voriconazole and echinocandins among all isolates. Mortality rate (1 month) were recorded as 40% (20/50). Among 33 patients whose control cultures were sended, microbiologic eradication were seen in 24 patients (72.7%) and mean duration of eradication were recorded as 7.6 days. Echocardiography was performed in 14% (7/50) and ophthalmic examination in 8%(4/50).
Conclusion: Although C.albicans is still major pathogen among candidemic patients, the numbers of non-albicans speices are increasing. Early diagnosis and treatment has a vital importance in candidemic patients due to high mortality rates.
C. Karaca, None
S. Hilmioglu-Polat, None
S. Ersin, None
M. Tasbakan, None