2353. Respiratory Syncytial Virus (RSV) in Preterm Infants: Epidemiology, Clinical Pattern and Risk Factors in a Pediatric hospital in Argentina.
Session: Poster Abstract Session: Pediatric Viral Infections
Saturday, October 6, 2018
Room: S Poster Hall
Posters
  • Poster 2353 IDweek 2018.pdf (623.3 kB)
  • Background: RSV is the main agent that causes Acute Lower Respiratory Tract Infection(ALRI) in children. Preterm infants(PT) have a higher risk of hospitalization and complications associated with RSV infection. The aim of this study was to describe epidemiology, clinical pattern and risk factors associated to RSV infection in PT infants.

    Methods: Prospective, Cross sectional study of patients admitted for ALRI, 2000-2017. Virological diagnosis was made by fluorescent antibody assay of nasopharyngeal aspirates or RT-PCR. We compared epidemiological and clinical features, complications and lethality between full term(FT) and PT infants. Logistic regression was performed to establish lethality risk factors in PT.

    Results: A total of 15,451 patients included, 13,033 were tested and 45%(5831) had positive samples; RSV was predominant (81.3%, 4738) all through the study period showing a seasonal epidemic pattern(May-July); 14% (655) were PT

    PT

    FT

    OR

    IC95%

    2-tailed p

    Gender

    58,47%

    56,19%

    1,1

    0,9

    1,3

    0,274

    Age(median)

    7 (4-13)

    7 (3-12)

    0,001

    Bronchiolitis

    60,15%

    61,39%

    0,9

    0,8

    1,1

    0,548

    Comorbidities

    56,34%

    38,75%

    2,0

    1,7

    2,4

    0,000

    Perinatal respiratory history

    46,56%

    5,46%

    15,1

    12,3

    18,5

    0,000

    Cardiopathy

    8,09%

    5,60%

    1,5

    1,1

    2,0

    0,012

    Malnourishment

    10,09%

    3,74%

    2,9

    2,1

    3,9

    0,000

    Chronic Respiratory Disease

    41,37%

    28,96%

    1,7

    1,5

    2,1

    0,000

    Bronchopulmonary Displasia

    5,95%

    0,05%

    128,8

    31,0

    534,9

    0,000

    Immunosupression

    1,07%

    1,97%

    0,5

    0,2

    1,2

    0,114

    Previous hospitalization(ALRI)

    41,74%

    23,94%

    2,3

    1,9

    2,7

    0,000

    Chronic Neurological Disease

    7,48%

    3,66%

    2,1

    1,5

    3,0

    0,000

    Re admission

    4,74%

    3,00%

    1,6

    1,1

    2,4

    0,020

    Lenth of stay(median)

    7 (5-10)

    8 (5-11)

    0,000

    ICU requirement

    10,84%

    7,55%

    1,5

    1,1

    2,0

    0,004

    Nosocomial infection

    7,86%

    6,01%

    1,3

    1,0

    1,8

    0,074

    Lethality

    3,09%

    1,54%

    2,0

    1,2

    3,4

    0,005

    Congenital cardiopathy OR3.41(1.12-10.3)p=0.003 and perinatal respiratory history OR3.1(1.6-6.1)p<0.001 were the independent predictors for VSR lethality in PT.

    Conclusion: RSV showed an epidemic pattern (May-July) and affected PT with certain comorbidities, with more severe disease, more complications during hospitalization and higher lethality than FT. RSV lethality in PT was more associated with congenital cardiopathy and perinatal respiratory history.

    Angela Gentile, MD1, Maria Florencia Lucion, MD2, Maria Del Valle Juarez, MD3, Maria Soledad Areso, MD3, Anabella Pacchiotti, MD4 and Vanesa Castellano, MD5, (1)Epidemiology, Epidemiology Department, "Ricardo Gutierrez"Children's Hospital, Buenos Aires, Argentina, (2)Epidemiology, "Ricardo Gutierrez" Children's Hospital, Buenos Aires, Argentina, (3)Epidemiology, Hospital de Niños "Ricardo Gutiérrez", Buenos Aires, Argentina, (4)Epidemiology, "Ricardo Gutiérrez" Children’s Hospital, Buenos Aires, Argentina, (5)Epidemiology, Ricardo Gutierrez Children's Hospital, Buenos Aires, Argentina

    Disclosures:

    A. Gentile, Sanofi Pasteur: Consultant , Speaker honorarium .

    M. F. Lucion, None

    M. D. V. Juarez, None

    M. S. Areso, None

    A. Pacchiotti, None

    V. Castellano, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.