450. Using Geographical Information Systems to Interpret the Efficacy of Mass Drug Administration for Soil-Transmitted Helminthiasis in Rural Madagascar
Session: Poster Abstract Session: Global Health and Travel Medicine
Thursday, October 4, 2018
Room: S Poster Hall

Background: In Madagascar, mass drug administration (MDA) of anti-parasitics is administered every six months to combat soil-transmitted helminthiasis (STH) in school-aged children, though little information exists as to its efficacy. In recent years, geographical information systems (GIS) has been used for visualization of patterns in disease epidemiology. This inexpensive technology may be leveraged to aid in education of local health workers towards a more integrated approach to control STH.

Methods: Baseline questionnaires and stool/blood samples were collected from participants of Mangevo, a rural village in southeast Madagascar. GPS coordinates and qualitative descriptions were collected from all village homes, common latrines, and animal pens. All children 5-15 years old were given MDA per WHO protocol. Stool was again collected from these children two weeks later and three months later. Parasitological examination of stool samples for STH eggs was performed using Spontaneous Sedimentation Technique. Results were overlaid onto GIS maps and used to further educate the local mobile health team.

Results: A total of 183 participants were eligible for the study. Analysis found 89% of adults >15 years old were infected with one or more parasite and 100% of children 5-15 were infected with one or more parasite at time 0. Trichuris trichuria prevalence fell 8% (p<0.5) in two weeks and climbed 17% (p<0.05) by three months follow up. Ascaris lumbricoides prevalence fell 96% (p<0.0001) in the two weeks and climbed 95% (p<0.0001) by three months follow up. Hookworm prevalence dropped 89% (p<0.0001) in two weeks and climbed 5% (p<0.5) by three months follow up. Prevalence data, descriptive results, and GPS coordinates of village homes were integrated into a GIS maps pre- and post-MDA of children, and pre-MDA for adults.

 

Conclusion: While GIS has been used to yield insights into the ecology of infection, this study examined the efficacy of the current MDA through the lens of small scale GIS mapping. This may be an ideal and inexpensive technology to help in the implementation of future interventions of the government-mandated STH treatment protocol and work towards the strengthening of local health teams.

Emile Redwood, BA, MD candidate1, Liana Langdon-Embry, BA, MD candidate1, Annabelle Jones, BS, MD candidate1, Benjamin Schwarz, BS, MD candidate1, Ando Lvasoa Rakotoniaina, MD2, Fara Nantenaina Rakotoarison, Midwife, Mobile Health Team2, Andry Andriamiadanarivo, Cartographer2, Patricia Wright, PHD3, Ines Vigan-Womas, PHD4, Peter Small, MD5 and Luis A. Marcos, MD, MPH6, (1)Stony Brook School of Medicine, Stony Brook, NY, (2)Centre Val Bio, Ranomafana, Madagascar, (3)Anthropology, Stony Brook University, Stony Brook, NY, (4)Institut Pasteur de Madagascar, Antananarivo, Madagascar, (5)Global Health Institute, Stony Brook School of Medicine, Stony Brook, NY, (6)Infectious Disease, Stony Brook University Hospital, Stony Brook, NY

Disclosures:

E. Redwood, None

L. Langdon-Embry, None

A. Jones, None

B. Schwarz, None

A. L. Rakotoniaina, None

F. N. Rakotoarison, None

A. Andriamiadanarivo, None

P. Wright, None

I. Vigan-Womas, None

P. Small, None

L. A. Marcos, None

Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.