Methods: We conducted a retrospective review of HIV-infected patients treated in the Ryan White Clinic of Jackson Memorial Hospital from January to December 2016. Of the 2065 patients who attended our clinic in 2016, a sample of 317 patients was obtained. Our aim was to determine the non-infectious comorbidities associated with high RDW (≥ 14%) in patients with undetectable HIV viral load. Data was analyzed in SPSS 22, New York, USA.
Results: Our study included 317 HIV patients with undetectable HIV viral load, 123 (38.8%) females and 194 (61.2%) males with a mean age of 54.3 (SD ± 9.94). Most patients were African American (52.4%) and Hispanic (39.4%). The mean CD4 count was 609.9 cells/uL (SD ± 303.48) with a mean CD4/CD8 ratio of 1.04 (SD ± 3.8). The mean RDW was 13.6 % (SD ± 2.08). High RDW was observed in 94 (29.7%) patients. Hepatitis B and C coinfection were found in 7.6% and 11.4% of patients respectively. 74 (23.3%) patients reported alcohol use and 103 (32.5%) patients disclosed smoking. Most patients were on antiretroviral therapy (98.4%).The preferred regimen was 2 NRTIs plus an integrase inhibitor (53%). The most frequent non-infectious comorbidities were dyslipidemia (56.8%), hypertension (52.4%), depression (26.8%) and diabetes mellitus (19.6%).
In comparison with the rest of the study cohort, the patients with high RDW had a higher proportion of hypertension (61.7% vs 48.4%, p=0.031), stroke (7.4% vs 0.9%, p=0.001), congestive heart failure (10.6% vs 2.7%, p=0.003) and chronic kidney disease (26.6% vs 10.3%, p<0.001). They also had significantly lower CD4 count (555.8 vs 632.7, p=0.039). No difference was found in myocardial infarction, peripheral vascular disease, dementia, COPD, asthma, cancer, liver disease, dyslipidemia, depression or gastric disease.
Conclusion: Hypertension, congestive heart failure, stroke and chronic kidney disease were conditions associated with high RDW. Our study suggests that high RDW may be a marker of cardiovascular and renal dysfunction in well-controlled HIV-infected patients.
J. Baez Presser,
M. Lorio Rugama, None
A. Milisavljevic, None
J. Gonzales Zamora, None
See more of: Poster Abstract Session