1516. Evaluating Appropriate Antimicrobial Selection and Duration of Therapy for Urinary Tract Infections in Outpatient Clinics
Session: Poster Abstract Session: Urinary Tract Infection
Friday, October 5, 2018
Room: S Poster Hall
  • 1516. Evaluating Appropriate Antimicrobial Selection and Duration of Therapy for Urinary Tract Infections in Outpatient Clinics - Melanie Green.pdf (1.2 MB)
  • Background: Each year in the United States, approximately 97 million outpatient visits result in the prescription of an antibiotic. However, there is limited data describing prescribing practices for urinary tract infections (UTIs) in outpatient clinics.   We aimed to describe the prescribing patterns for UTIs among varied provider groups and clinic subspecialties, in order to improve targeted interventions to improve antibiotic use.

    Methods: This retrospective study included patients from 1/2016 through 12/2016 within a large academic healthcare system presenting to 30 clinics, including family medicine, general medicine, urology, geriatric, and OB/GYN. Patients were included if they had a diagnosis of a lower tract UTI (ICD-10 codes for acute cystitis (N30) and cystitis with or without hematuria (N30.90-91). Exclusions included pregnancy, prophylaxis prior to urology procedure, antibiotics not prescribed, or antibiotic prophylaxis. Patients were categorized as complicated versus uncomplicated based on additional ICD-10 codes for uncontrolled diabetes, urinary obstruction, flank pain, renal failure, gender, and receiving immunosuppression.  Additionally, patient allergies were evaluated to assess adherence to guidelines [Figure 1].  The primary objective was to describe prescriber compliance with institutional UTI guidelines for both drug selection and duration.

    Results: From 30 clinics, 1488 patient encounters for UTI were included. The overall compliance rate was 9.5% for appropriate drug selection and duration of therapy, with appropriate drug selection (22.8%) being much lower than appropriate duration (84.9%). The most commonly prescribed antibiotics included trimethoprim/sulfamethoxazole (31.8%), FQs (23.2%) and nitrofurantoin (21.7%). Compliance rates varied widely between prescriber types [Figure 2.]

    Conclusion: Management of UTIs in outpatient clinics is suboptimal, and would benefit from antimicrobial stewardship interventions.  Stewardship efforts in outpatient clinics should target both appropriate drug selection and duration, and de-emphasize FQ use.

    Figure 1: Michigan Medicine Guidelines for Empiric Outpatient UTI Treatment

    Figure 2: Prescribing Compliance Stratified by Prescriber Type


    Melanie Green, PharmD, University of Michigan College of Pharmacy, Ann Arbor, MI, Jerod Nagel, PharmD, BCPS, University of Michigan Department of Pharmacy Services, Ann Arbor, MI and Lindsay Petty, MD, Internal Medicine, Division of Infectious Diseases, Michigan Medicine, Ann Arbor, MI


    M. Green, None

    J. Nagel, None

    L. Petty, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.