349. Retrospective Descriptive Analysis of West Nile Neuroinvasive Disease in Northwest Louisiana
Session: Poster Abstract Session: CNS Infections
Thursday, October 4, 2018
Room: S Poster Hall
Background:

West Nile virus (WNV) infection has become endemic in the continental United States. 80% of the West Nile virus infections are asymptomatic. 1 in 150 individuals with West Nile virus infection develops West Nile neuroinvasive disease (WNND) . The neurological manifestations include encephalitis, meningoencephalitis, meningitis and acute flaccid paralysis.

Methods:

We performed a retrospective descriptive study in our tertiary care hospital in Louisiana to describe the clinical features, Cerebrospinal Fluid (CSF) findings and clinical outcomes. Patient age >18 admitted in our hospital between January 1, 2012 and December 31, 2017 were included. Hospital Electronic Health records were screened for diagnosis of WNND by ICD codes and Positive WNV antibody testing in CSF.

Results:

There were a total of 23 patients identified with positive WNV IgM or IgG in CSF. 15 patients were males and 8 were female. The median age was 48.8 years. 6 patients were diagnosed with meningitis, 12 with encephalitis and 5 with meningoencephalitis. Most Common presenting symptoms were altered mental status and fever in 15 patients . Only 2 patients gave history of mosquito bite. Incidence was peak in the month of August , July and September.

WNV IgG and IgM antibodies were positive in CSF in 13 patients. 4 patients had only positive WNV IgM and 6 patients had only positive WNV IgG . The average number of days from the admission to diagnosis of infection ranged from 3 to 16 days with average of 8.9 days. CSF protein was >45mg/dL in 12 patients and Elevated white cell count (>5mm3) in 20 patients. CSF Protein >100 mg/dL was seen in 9 patients. Lymphocytosis was present in 10 patients.The average length of stay was 13.3 days and 9 patients required ICU stay. Only 1 patient was not given any antibiotics. The average duration of antibiotics was 6.4 days. On one year follow up, 8 patients had no residual deficits, 4 patients had residual deficits, 2 patients were deceased and 9 patients were lost to follow up.

Conclusion:

WNV infection has become endemic in Southern United States especially in summer months. Identifying the infection early in its clinical course would help to avoid unnecessary antibiotics when patients present with fever and meningeal symptoms. Including WNV antibodies in CSF studies is critical in making a diagnosis.

Pradeep Mada, MD1, Philip Sneed, MD2, Gabriel Castano, MD3, Maureen Moore, Co-ordinator4 and Andrew Stevenson Joel Chandranesan, MD4, (1)Infectious Diseases, Louisiana State University Health Science Center, Shreveport, LA, (2)Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, (3)Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, (4)Infectious Diseases, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA

Disclosures:

P. Mada, None

P. Sneed, None

G. Castano, None

M. Moore, None

A. S. Joel Chandranesan, None

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