Objectives: To determine the incidence rate of CPKP colonizationand risk factors of 30-day-hospital mortality in HSCT patients at King Chulalongkorn Memorial Hospital.
Methods: A prospective study was conducted in total of 96 consecutive HSCT patients at King Chulalongkorn Memorial Hospital, Bangkok, Thailand, from July 2016 to 31 March 2018.
Results: Incidence rate of CPKP colonizationin HSCT patients was 22.2% (18/96 patients) and incidence rate of CPKP infections was 5.2% (5/96 patients). Both blaOXA-48 and blaNDMwas the most common carbapenemase gene (50%). Patients with CPKP infection were more likely in ICU setting than colonization group. CPKP colonization was more significantly found in urinary specimens (P= 0.029) whereas CPKP infections were common found in respiratory tract, but not significantly (P=0.583). In CPKP infection group, the 30-day mortality rate was significantly higher than colonization group; 80% (4/5) versus 23% (3/13), P= 0.047). Using univariable analysis, ICU setting was associated with CPKP infection (RR=6.27 95% CI, 0.87–45.34) and had a worse outcome.The risk factor associated with 30-day mortality was CPKP infection (RR=3.47 95% CI, 1.17–10.26).
Conclusion: In our study, the incidence of CPKP colonization in HSCT patients was 22.2%. The incidence of CPKP infections found only 5.2% in HSCT patients but there was significantly associated with increased 30-day-hospital mortality.
J. Vanichanan, None
K. Jutivorakool, None
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