Session: Poster Abstract Session: HIV: Molecular Epidemiology
Friday, October 5, 2018
Room: S Poster Hall
  • ID-Week 2018 GEOSPATIAL SPREAD OF HIV 19.09.2018 ms.pdf (1.0 MB)
  • Background: Geographical targeting of interventions of hotspots of HIV transmission increases the impact of HIV intervention. We combined molecular epidemiology and geospatial analyses to provide insights into the drivers of HIV transmission and the contribution of geographical hot spots to the rapidly evolving local HIV epidemic of Cologne-Bonn.

    Methods: We included 714 HIV-1 infected ART naïve individuals, followed at the University Hospitals Cologne and Bonn between 2001 and 2016. Phylogenetic and network analyses were performed to infer putative relationships. Assortativity index (AI, i.e. shared attributes) and characteristics of genetically linked individuals were analyzed. The geospatial diffusion of the local epidemic (i.e. viral gene flow) was evaluated using a Slatkin-Maddison approach. Geospatial dispersal of local HIV transmission was determined by calculating the average distance between genetically linked individuals (centroids of 3-digit zip code of residency, ArcGIS®).

    Results: 217/714 (30.4%) sequences had a putative linkage with at least one other sequence, forming 77 clusters (size range: 2-8). Genetically linked individuals were significantly more likely to live in suburban areas (p=0.035), <30 years of age (p=0.013), infected with HIV-1 subtype B (p=0.002). AI for concurrent area of residency showed that individuals were non-assortative in the network (-0.0026, p=0.046), indicating that clustering individuals tended to cluster with individuals living in a different zip code. Geospatial analyses revealed that the median distance between genetically linked individuals was 23.4 kilometers (km), significantly lower than expected (median 39.68 km; p<0.001) (Fig. 1A). Slatkin Maddison analyses revealed increased gene flow originating from Central Cologne toward the surrounding areas (p<0.001, Fig. 1B).

    Conclusion: Phylogeographic analysis suggests that central Cologne may be a significant driver of the regional epidemic. While clustering individuals lived closer than unlinked individuals, they were less likely to be linked to others from their same zip code. This may reflect individuals reaching out of their neighborhoods and social circles to meet new partners.

    Melanie Stecher, MSc. Public Health1,2, Martin Hoenigl, MD3, Anna-Maria Eis-Huebinger, Prof.4, Clara Lehmann, PD Dr. med.1,2, Gerd Fätkenheuer, Univ.-Prof. Dr. med.1,2, Jan-Christian Wasmuth, MD4, Elena Knops, PhD2, Sanjay Metha, Prof.3, Janne Vehreschild, Prof. Dr. med.5 and Antoine Chaillon, MD, PhD3, (1)German Center for Infection Research, Cologne-Bonn, Cologne, Germany, (2)University Hospital of Cologne, Cologne, Germany, (3)University of California San Diego, San Diego, CA, (4)University Hopital of Bonn, Bonn, Germany, (5)Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany


    M. Stecher, None

    M. Hoenigl, None

    A. M. Eis-Huebinger, None

    C. Lehmann, None

    G. Fätkenheuer, None

    J. C. Wasmuth, None

    E. Knops, None

    S. Metha, None

    J. Vehreschild, None

    A. Chaillon, None

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