715. Increase in Reported Respiratory Syncytial Virus Cases among Adults in the Minneapolis-St. Paul Metropolitan Area, 2014-2018
Session: Poster Abstract Session: Respiratory Infections: Viral
Thursday, October 4, 2018
Room: S Poster Hall
  • RSV Poster IDWeek Final.pdf (445.8 kB)
  • Background: Respiratory syncytial virus (RSV) is a common cause of respiratory infection, typically causing severe disease in young children. We were interested in evaluating trends of severe RSV infections in adults.

    Methods: The Minnesota Department of Health conducts active surveillance for laboratory-confirmed RSV in hospitalized patients in the Minneapolis-St. Paul metropolitan area as part of the CDC Emerging Infections Program. Adults (≥ 18 yrs) cases identified during the RSV season (10/1 to 4/30) from 2014 through 2018 were analyzed and surveys of catchment-area hospital laboratories were conducted regarding respiratory virus panel (RVP) testing.

    Results: 23 catchment area hospitals serve adults. 4 hospitals offered RVP during the 2014-15 and 2015-16 seasons; 8 offered RVP during the 2016-17 and 2017-18 seasons. 355 cases were identified. 309 (87%) were reported from 4 hospitals where RVP was offered throughout the study period. Case increases were observed at 3 hospitals; all of these hospitals offered RVP throughout the surveillance period; increases were not observed at hospitals where RVP was added for the 2016-17 and 2017-18 seasons. Cases increased from 42 in 2014-15 to 198 in 2017-18 (X2=125.51,p<0.01), the proportion of cases reported by year was 12%, 15%, 17% and 56% during consecutive seasons. Cases by age groups over time generally did not differ; however, cases ≥85 yrs increased from 7% of total cases in 2014-15 to 19% in 2017-18 (X2=6.14, p=0.01). Overall, 23% of cases were admitted to the ICU and 7% died during hospitalization. The proportion of ICU admissions and deaths did not change over time.

    Conclusion: We found an increase in adult RSV hospitalizations from 2014 to 2018, especially among the oldest age group. This increase was observed only at hospitals where RVP testing was offered throughout the surveillance period. It is unclear if this represents a true increase in RSV or a change in testing practices. However, it does illustrate that RSV should be considered as a cause of severe respiratory illness (SARI) in adults, particularly among the elderly. A more systematic approach in identifying the causes of SARI in adults would be informative, particularly as RSV vaccines and antivirals approach licensure.

    Kathryn Como-Sabetti, MPH1, Erica Bye, MPH2, Anna Strain, PhD3, Melissa McMahon, MPH3 and Ruth Lynfield, MD, FIDSA3, (1)Minnesota Department of Health, Saint Paul, MN, (2)Minnesota Department of Health, St Paul, MN, (3)Minnesota Department of Health, St. Paul, MN


    K. Como-Sabetti, None

    E. Bye, None

    A. Strain, None

    M. McMahon, None

    R. Lynfield, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.