791. Hyponatremia Incidence and its Association with Mortality in Patients with Tuberculosis
Session: Poster Abstract Session: Tuberculosis and Other Mycobacterial Infections
Thursday, October 4, 2018
Room: S Poster Hall
Posters
  • IDSA.pdf (3.5 MB)
  •   Background:

    In 2014, 26,000 new cases of tuberculosis were reported in Mexico. TB infection can cause hyponatremia which has a strong association with mortality. The objective of this study was to determine the association of mortality with hyponatremia in patients with tuberculosis infection.

      Methods:

    Patients were collected from a 2-year period in the Hospital Dr. Bernardo Sepœlveda in Nuevo Le—n, Mexico. Inclusion criteria were patients >18 years of age, with positive tuberculosis tests, and sodium and serum glucose values upon admission.

    Clinical data from the electronic file was collected and analyzed by descriptive statistics; Student's t-test and chi-square test were used to compare categorical variables, and Kaplan-Meier to estimate survival curves.

      Results:

    There were 314 patients with suspected TB, 77 patients were included (Table 1).

    CHARACTERISTICS

    TOTAL
    N=77

    NORMAL SODIUM
    N=23

    HYPONATREMIA
    N=54

    P

    AGE, MEAN (SD)

    41.46 (16.22)

    41.25 (16.32)

    41.44 (16.08)

     

    SEX

     

     

     

     

         FEMALE, %

    26 (33.7%)

    8 (34.7%)

    18 (33.3%)

    0.90

    INFECTION

     

     

     

    0.63

         PULMONARY

    66 (85.7%)

    20 (86.9%)

    46 (85.18%)

     

         PLEURAL

    6 (7.7%)

    2 (8.6%)

    4 (7.4%)

     

         MENINGEAL

    3 (3.8%)

     

    3 (5.5%)

     

         DISSEMINATED

    2 (2.5%)

    1 (4.3%)

    1 (1.8%)

     

    SERUM SODIUM, MEAN (SD)

    131.08 (6.1)

     

     

     

    COMORBIDITIES

     

     

     

     

         DIABETES  

    26 (33.7%)

    9 (39.1%)

    17 (31.4%)

    0.51

         CIRRHOSIS

    4 (5.1%)

     

    4 (7.4%)

    0.18

         HIV

    14 (18.1%)

    1 (4.3%)

    13 (42.5%)

    0.04

    CHARLSON COMORBIDITY INDEX, MEAN (SD)

    2.09 (2.38)

    2.06 (2.38)

    2.07 (2.39)

     

    DRUGS

     

     

     

     

         DIURETICS

    3 (3.8%)

    1 (4.3%)

    2 (3.7%)

    0.89

         ARV

    5 (6.4%)

     

    5 (9.2%)

    0.13

    HOSPITALIZED

    71 (92.2%)

    22 (95.6%)

    49 (90.7%)

     

    SURVIVAL, MEAN(SD) MONTHS

    6.5 (7.15)

     

     

     

    MORTALITY, %

    28 (36.3%)

    7 (30.4%)

    21 (38.8%)

    0.48

    Table 1. Patient characteristics.

    Mean follow-up was 6.5 ± 7.1 months. Overall mortality rate was 36.3%. Analysis of mortality is presented in Fig 2, and in severe hyponatremia in Fig 3.

      Conclusion:

    Overall mortality was higher than previously reported, but there was no statistical association between hyponatremia and mortality compared with patients with normal sodium, or by severity. Within the limitations of this study, we must consider that 92% of patients were hospitalized patients at the time of diagnosis, implying that they were patients with complications and may be the reason why both mortality and the incidence of hyponatremia were higher.

    Andrea Llamas-Lopez, Internal Medicine Resident1, Tania Vargas, Internal Medicine Resident2, Luis Morales-Garza, M.D.3 and Rogelio Maya, M.D.2, (1)Medicina Interna, Tecnologico de Monterrey, Monterrey, Mexico, (2)Tecnologico de Monterrey, Monterrey, Mexico, (3)Internal Medicine, Tecnologico de Monterrey, Monterrey, Mexico

    Disclosures:

    A. Llamas-Lopez, None

    T. Vargas, None

    L. Morales-Garza, None

    R. Maya, None

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