1561. Outcomes of Resistant or Refractory CMV Infection in Recipients of Allogeneic Hematopoietic Cell Transplant
Session: Poster Abstract Session: Viruses and Bacteria in Immunocompromised Patients
Friday, October 5, 2018
Room: S Poster Hall
Background: Resistant or refractory CMV infections are not well defined and may be associated with high morbidity and mortality in allogeneic hematopoietic cell transplant (allo-HCT) recipients. Suspicion of resistant CMV infections is usually based on suboptimal responses to antiviral agents.

Methods: We performed a single center retrospective chart review (1/2010 to 9/2017) of Allo-HCT recipients who had CMV genotypic testing performed for suspected antiviral resistance. Based on the results, we categorized patients as either having refractory CMV (defined as CMV viremia that fails to decrease after at least 2 weeks of appropriately dosed and delivered antiviral therapy; and in the absence of known genetic mutations to the available antiviral agents) or resistant CMV infection (defined as refractory infection with identification of genetic mutations in the UL97 and/or UL54 genes correlating with in vitro antiviral resistance). Primary outcome was all-cause mortality.

Results: CMV genotypic resistance analysis was performed in 97 patients. Of those, 23 had resistant (11 had UL54 gene, 10 had UL 97 gene, and 2 had both UL 54 and 97) and 74 had refractory CMV infections. The majority of patients had AML (53%), underwent matched unrelated donor transplantation (43%), and received ATG during conditioning (64%). Patients with resistant CMV infections had a greater number of prior episodes when compared to those with refractory infections and had a longer time from transplant to suspicion of resistance (p < 0.01; each). Overall, the incidence of CMV disease was 41% (25% vs. 58% affecting the lungs and 56% vs. 17% the GI tract, in resistant vs. refractory infections, respectively). All-cause mortality was 57% (61% resistant vs. 55% refractory) and CMV-attributable mortality was 11% (9% resistant vs. 12% refractory).

Conclusion: Our data showed that resistant CMV infections are associated with a higher rate of CMV disease. However, both resistant and refractory CMV infections had increased all-cause mortality and similar CMV-attributable mortality. There was no difference in outcomes between allo-HCT recipients who had resistant or refractory CMV infections. New treatment strategies for resistant or refractory CMV infections are needed.

Annette Artau, MD1, Samuel L. Aitken, PharmD2, Marjorie Batista, MD, PhD1, Firas El Chaer, MD3, Amrita Prayag, MD1, Lynn El Haddad, PhD1, Victor Mulanovich, MD1, Ella Ariza-Heredia, MD4 and Roy Chemaly, MD, MPH1, (1)The University of Texas MD Anderson Cancer Center, Houston, TX, (2)Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX, (3)University of Maryland Greenebaum Cancer Center, Baltimore, MD, (4)Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX

Disclosures:

A. Artau, None

S. L. Aitken, Merck: Speaker's Bureau , Consulting fee .

M. Batista, None

F. El Chaer, None

A. Prayag, None

L. El Haddad, None

V. Mulanovich, None

E. Ariza-Heredia, Oxford Immunotec: Grant Investigator , Research grant .

R. Chemaly, Merck: Consultant , Research grant . Chimerix: Consultant , Research grant . Novartis: Investigator , Research grant . Oxford Immunotec: Consultant , Research grant .

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