Hand hygiene and isolation precaution are often difficult to sustain, requiring additional measure to control multidrug resistant organisms (MDRO) transmission. It was suggested that continuously antimicrobial surfaces could offer superior control of surface bioburden.Thus, we sought to decide the efficacy of photocatalyst antimicrobial coating in reducing MDRO acquisition in high incidence setting.
At an institute where used to have high incidence rate of methicillin-resistant Staphylococcus aureus (MRSA), we performed prospective cohort study involving patients hospitalized in medical intensive care unit. 5 months of pre intervention (where routine infection control measures were maintained) data were compared with 5 months of post intervention (after titanium dioxide-based photocatalyst were coated on high touch surfaces) data. The acquisition rate of MDROs and the rates of hospital acquired blood stream infection (BSI), pneumonia, urinary tract infection (UTI) and Clostridium difficile associated disease (CDAD) were compared using Cox proportional hazards regression analysis.
A total of 621 patients were included. There was significant decrease in MRSA acquisition rate after photocatalyst antimicrobial coating. (Hazard ratio, 0.37; 95% CI, 0.14-0.99; p= 0.04). However, acquisition rates of vancomycin resistant Enterococcus spp. and multidrug resistant Acinetobacter baunmannii had not significantly decreased. The hazard of acquiring hospital acquired pneumonia during intervention period compared to baseline period was 0.46 (95% CI, 0.23-0.94; p= 0.03). There weren’t significant reduction in hospital acquired BSI, UTI and CDAD, after photocatalyst antimicrobial coating.
Conclusion: MRSA acquisition rate and hospital acquired pneumonia were significantly reduced after photocatalyst antimicrobial coating. This study provides evidence that photocatalyst antimicrobial disinfection can be an adjunctive measure to control MRSA acquisition in high incidence setting.
M. H. Kim,
S. G. Lee, None
K. S. Kim, None
Y. J. Heo, None
J. E. Oh, None
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