56. Kaposi Sarcoma manifestations in women during the established antiretroviral era: a case-series in an urban hospital in southern USA
Session: Posters in the Park: Posters in the Park
Wednesday, October 3, 2018: 5:30 PM
Room: N Hall D Opening Reception and Posters in the Park Area
Posters
  • KS in Women Poster Final.pdf (853.8 kB)
  • Background:

    Kaposi sarcoma (KS) is one of the Acquired Immuno-Deficiency Syndrome (AIDS)-associated malignancies and is more common in men than in women. A large international observational study cohort in the established antiretroviral (ART) era showed that the rate of AIDS-associated KS in Europe and the Americas is 6 times higher in men than in women. We report our experience with Kaposi sarcoma in women in a safety-net hospital in Atlanta, Georgia.

    Methods:

    This is a descriptive case – series of all HIV-positive women who had a tissue diagnosis of KS between 8/1/2013 to 4/15/2018. Demographics, symptoms presentation, laboratory data, treatment, and outcomes were abstracted from the electronic medical records.

    Results:

    Of 102 individuals with tissue – confirmed KS during this period, there were 5 women: 4 were Black (2 were born in USA and 2 immigrated from Africa) and 1 was Caucasian. Their median age was 40 years (range: 35-56), their median CD4+ cell count at KS diagnosis was 8.3 cells/mm3 (range: 3-274) with a median log10 viral load copies/mL of 5 (range: 2.26-5.38). There was a median of 56 days (range: 26-365) from onset of symptoms to KS diagnosis. KS occurred an average of 4 years (range: 0.6-15) after HIV diagnosis. The majority had KS disease with cutaneous and visceral (pulmonary or gastrointestinal) involvement. Only 1(20%) was on ART at KS diagnosis and 4 (80%) received ART after KS diagnosis. KS was treated with liposomal doxorubicin in 2 women; 1 received radiation to her oropharyngeal lesion. One woman died shortly after her KS diagnosis from shock and multiorgan failure.

    Conclusion:

    Kaposi sarcoma remains a rare but serious complication of AIDS in women. Providers should be vigilant in recognizing early signs of KS in AIDS-infected women to allow timely diagnosis and therapy of this treatable disease.

    Anisha Apte, BS, Emory University School of Medicine, Atlanta, GA, Clifford Gunthel, MD, Medicine, Emory University School of Medicine/Division of Infectious Diseases, Atlanta, GA; GRADY HEALTH SYSTEM, Atlanta, GA, Marina Mosunjac, MD, Department of Pathology, Emory University School of Medicine, Atlanta, GA and Minh Ly Nguyen, MD, MPH, FACP, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA; Grady Health system, Atlanta, GA

    Disclosures:

    A. Apte, None

    C. Gunthel, None

    M. Mosunjac, None

    M. L. Nguyen, None

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