2149. Real-time Nationwide Surveillance for Antimicrobial Resistance of Major Pathogens using Automated Data Collection System in Korea: a KARS-Net Study
Session: Poster Abstract Session: Healthcare Epidemiology: Epidemiologic Methods
Saturday, October 6, 2018
Room: S Poster Hall

Background: Information on the most current status of antimicrobial resistance (AMR) in local and national levels has critical importance. However, collection and analysis of a large number of antimicrobial susceptibility test (AST) results often results in additional workload in healthcare facilities and latency in final reporting. We sought to develop an automated nationwide surveillance network in Korea.

Methods: Data collection servers were set up at each participating institutions, which collects AST results of every bacterial isolate from blood, cerebrospinal fluids, urine, and respiratory specimens. Collected results are anonymized and transmitted to central data server every day without human input. End-user can perform various analyses using data warehouse server through web interface. Only first isolates of same species from individual patients were included in analysis.

Results: A total of 19 hospitals located in various regions in Korea participated to the network. From Jan 2015 through Dec 2017, AST results of 347,356 isolates were collected. The proportion of MRSA among S. aureus (n=17,761) was 65.3%, which declined gradually from 71.5% to 62.3% during study period (p<0.001). The proportion of VRE increased from 29.3% to 36.3% (p=0.001). Resistance rates of E. coli (n=63,628) to 3rd and 4th generation cephalosporins, fluoroquinolone, and piperacillin-tazobactam were 31.6%, 23.0%, 44.0%, and 4.2%, respectively. Resistance rates of K. pneumoniae (n=16,875) to same classes were 32.2%, 28.1%, 31.0% and 19.1%, respectively. Among E. coli and K. pneumoniae, 0.4% and 4.3% were resistant to carbapenem. Resistance rates of P. aeruginosa (n=12,895) to carbapenem was 30.5%. However, 72.7% of A. baumannii isolates (n=9,885) were resistant to carbapenem. Colistin resistance rate was still low at 0.5%.

Conclusion: We have established a fully automated nationwide surveillance network for AMR in Korea. Our system provided data on the most current status of AMR, which revealed increase in resistance rates among major gram-negative pathogens compared to previous studies.

 

 

Figure 1. Schematic diagram of the Korean Antimicrobial Resistance Surveillance Network (KARSNet).

Figure 2. Temporal trends of the resistance rates of S. aureus and E. faecium.

Figure 3. Temporal trends of the resistance rates of major gram-negative species.

Kyungmin Huh, MD, MSc1, Young Eun Ha, MD2, Doo Ryeon Chung, MD2, Jae-Hoon Ko, MD3, Hyunsoo Kim, MD4, Dongeun Yong, MD, PhD5, Kyungwon Lee, MD, PhD5, Hee Jae Huh, MD6, Nam Yong Lee, MD, PhD7, Suhyun Oh, MD1, Sukbin Jang, MD1, Seokjun Mun, MD1, Cheol-In Kang, MD1, Kyong Ran Peck, MD1, Jae-Hoon Song, MD, PhD2 and the Korean Antimicrobial Resistance Surveillance Network (KARS-Net) investigators, (1)Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), (2)Samsung Medical Center, Seoul, Korea, Republic of (South), (3)Division of Infectious Diseases, Armed Forces Capital Hospital, Seongnam, Korea, Republic of (South), (4)Department of Laboratory Medicine, The National Police Hospital, Seoul, Korea, Republic of (South), (5)Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of (South), (6)Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), (7)Department of Laboratory Medicine and Genetics, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea, Republic of (South)

Disclosures:

K. Huh, None

Y. E. Ha, None

D. R. Chung, None

J. H. Ko, None

H. Kim, None

D. Yong, None

K. Lee, None

H. J. Huh, None

N. Y. Lee, None

S. Oh, None

S. Jang, None

S. Mun, None

C. I. Kang, None

K. R. Peck, None

J. H. Song, None

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