682. The Changing Epidemiology of Bacterial Meningitis During 2015-2017 in Turkey: A Hospital Based Prospective Surveillance Study.
Session: Poster Abstract Session: Public Health: Epidemiology and Outbreaks
Thursday, October 4, 2018
Room: S Poster Hall
Posters
  • poster IDweek 2018.pdf (555.9 kB)
  • Background: The etiology of bacterial meningitis in Turkey has been changed after the implementation of conjugated vaccines against Streptococcus pneumonia and Haemophilus influenzae type b (Hib) in Turkish national immunization schedule.Methods: This prospective study was conducted in 25 hospitals located 7 regions of Turkey (representing 30% of Turkey population) and children aged between 1 month and 18 years with suspected meningitis and hospitalized were included. Cerebrospinal fluid samples were collected and bacterial identification was made according to the multiplex PCR assay results.Results: During the study period 927 children were hospitalized for suspected meningitis and Hib (n:1), S. pneumonia (n:17) and Neisseria meningitidis (n:59) were detected in 77 samples (Figure 1, Table 1).   During 2015-2016, N. meningitidis  serogroup W, B, A, Y, X frequencies were as 5 (13.9 %), 16 (44.4 %), 1 (2.8 %), 1 (2.8 %), 1 (2.8 %) respectively. There were 12 nongroupable N. meningitidis samples and  serogroup C wasn’t detected.  In 2017, of  meningococcal meningitis serogroup B, W, A, Y and X were identified in  2 (8.7 %), 15 ( 65.2 %), 2 (8.7 %), 1 ( 4.3 %) and 1 (4.3 %) cases, respectively ( Figure 2).  There were four death in this study period, all of them were caused by N. meningitidis serogroup B and three of them were under 1 year old.Conclusion:The epidemiology of meningococcal diseases has been vary in time with or without any apparent reasons. Hajj is a well known cause for serogroup W epidemics and serogorup W was the most common cause of meningitis in Turkey during 2009-2014 as in other Middle East countries.  After the impact of serogroup W epidemics related to Hajj seen in 2010’s was diminished, serogroup B has been leading cause of childhood meningitis since 2015.  In countries affected from Hajj like Turkey, vaccination of children with serogroup B meningococcal vaccine as well as quadrivalent conjugated vaccine seems to be very important.  It should be kept in mind that meningococcal epidemiology is dynamic and needed to be closely monitored to detect changes in years

    Figure 1. Distribution of causative agents of bacterial meningitis in Turkey during 2005-2017

     

    Figure 2.  Distribution of  meningococcal serogroups of meningococcal meningitis in Turkey during 2015-2017 and comparison with  results belonging to previous years.

    Mehmet Ceyhan, MD1, Yasemin Ozsurekci, MD1, Cihangül Bayhan, MD1, Nezahat Gurler, MD2, Enes Sali, MD3, Melike Keser Emiroglu, MD4, Fatma Nur Öz, MD5, Yıldız Camcioglu, MD6, Nuran Salman, MD7, Zafer Kurugol, MD8, Havva Ozlem Altay Akisoglu, MD9, Nilden Tuygun, MD10, Nursen Belet, MD11, Emel Ulusoy, MD12, Ener Cagri Dinleyici, MD13, Hasan Tezer, MD14, Aslınur Parlakay, MD15, Adem Karbuz, MD16, Fesih Aktar, MD17, Mustafa Hacimustafaoglu, MD18, Sevgen Tanır Basaranoglu, MD1, Kubra Aykac, MD1, Emine Kocabas, MD19, Ozlem Ozgur Gundeslioglu, MD19, Nevin Hatipoglu, MD20, Sadık Sami Hatipoglu, MD20, Gülnar Şensoy, MD21, Eda Karadag Oncel, MD22, Mehmet Ali Solmaz, MD23, Soner Sertan Kara, MD24, Solmaz Çelebi, MD18, Ümit Çelik, MD25, Özge Metin, M.D.26, Şefika Bozdemir, MD27, Ilker Devrim, MD28, Ahu Kara, MD28 and Murat Sütçü, M.D.29, (1)Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey, (2)Department of Microbiology and Clinical Microbiology, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey, (3)Department of Pediatric Infectious Diseases, Sanliurfa Training and Research Hospital, Şanlıurfa, Turkey, (4)Department of Pediatric Infectious Diseases, Selcuk University Faculty of Medicine, Konya, Turkey, (5)Department of Pediatric Infectious Diseases, Dr. Sami Ulus Maternity and Children's Training and Research Hospital, Ankara, Turkey, (6)Department of Immunology-Allergy and Infectious Diseases, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey, (7)Department of Pediatric Infectious Diseases, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey, (8)Department of Pediatric Infectious Diseases, Ege University Faculty of Medicine, Izmir, Turkey, (9)Department of Microbiology, Dr. Sami Ulus Maternity and Children's Training and Research Hospital, Ankara, Turkey, (10)Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Training and Research Hospital, ankara, Turkey, (11)Department of Pediatric Infectious Diseases, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, (12)Department of Pediatric Emergency Care, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, (13)Department of Pediatric Intensive Care and Infectious Disease Unit, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey, (14)Department of Pediatric Infectious Diseases, Gazi Univeristy Faculty of Medicine, Ankara, Turkey, (15)Department of Pediatric Infectious Diseases, Ankara Hematology Oncology Children's Training and Research Hospital, Ankara, Turkey, (16)Department of Pediatric Infectious Diseases, Okmeydani Training and Research Hospital, Istanbul, Turkey, (17)Department of Pediatrics, Dicle University Faculty of Medicine, Diyarbakir, Turkey, (18)Department of Pediatric Infectious Diseases, Uludag University Faculty of Medicine, Bursa, Turkey, (19)Department of Pediatric Infectious Diseases, Cukurova University Faculty of Medicine, Adana, Turkey, (20)Department of Pediatric Infectious Diseases, Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey, (21)Department of Pediatric Infectious Diseases, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey, (22)Department of Pediatric Infectious Diseases, İzmir Tepecik Training and Research Hospital, İzmir, Turkey, (23)Department of Pediatrics, Van Training and Research Hospital, Van, Turkey, (24)Department of Pediatric Infectious Diseases, Erzurum Training and Research Hospital, Erzurum, Turkey, (25)Department of Pediatric Infectious Diseases, Adana Numune Training and Research Hospital, Adana, Turkey, (26)Department of Pediatric Infectious Diseases, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey, (27)Department of Pediatric Infectious Diseases, Kayseri Training and Research Hospital, Kayseri, Turkey, (28)Department of Pediatric Infectious Disease, Dr. Behcet Uz Children's Hospital, Izmir, Turkey, (29)Department of Pediatric Infectious Diseases, Konya Training and Research Hospital, Konya, Turkey

    Disclosures:

    M. Ceyhan, None

    Y. Ozsurekci, None

    C. Bayhan, None

    N. Gurler, None

    E. Sali, None

    M. Keser Emiroglu, None

    F. N. Öz, None

    Y. Camcioglu, None

    N. Salman, None

    Z. Kurugol, None

    H. O. Altay Akisoglu, None

    N. Tuygun, None

    N. Belet, None

    E. Ulusoy, None

    E. C. Dinleyici, None

    H. Tezer, None

    A. Parlakay, None

    A. Karbuz, None

    F. Aktar, None

    M. Hacimustafaoglu, None

    S. Tanır Basaranoglu, None

    K. Aykac, None

    E. Kocabas, None

    O. Ozgur Gundeslioglu, None

    N. Hatipoglu, None

    S. S. Hatipoglu, None

    G. Şensoy, None

    E. Karadag Oncel, None

    M. A. Solmaz, None

    S. S. Kara, None

    S. Çelebi, None

    Ü. Çelik, None

    Ö. Metin, None

    Ş. Bozdemir, None

    I. Devrim, None

    A. Kara, None

    M. Sütçü, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.