1026. Trends in Infective Endocarditis During the Substance Use Disorder Epidemic at an Academic Medical Center
Session: Poster Abstract Session: Bacteremia and Endocarditis
Friday, October 5, 2018
Room: S Poster Hall

In many areas of the United States, substance use disorders (SUD) have increased dramatically over the past decade. Overdose deaths have increased as well, and Kentucky ranks among the nation’s leaders in deaths per 100,000 population. Infective Endocarditis (IE) is a well-known complication of intravenous drug use, contributing to significant morbidity and mortality, but few studies have evaluated the effect of the current SUD epidemic on rates and demographics of IE. We sought to examine the trends in IE and IE with SUD at our institution.


We collected data from patients admitted to a large academic medical center in Kentucky between January 1, 2013 and December 31, 2016. Patients were classified according to the International Classification of Diseases, Tenth Revision. Patients were considered to have IE if they received codes I33 or I38. Patients were considered to have a SUD if they received codes F11.10, F15.10, F14.10, F19.10, or Z86.59. Data were collected through the TriNetX database (TriNetX, Cambridge, MA).


There were 2100 cases of IE during the study period. The mean (SD) age was 53 years (21). Of those, 440 also had a SUD. The mean (SD) age of these patients was 41 years (11). Patients in both the IE and IE/SUD categories were primarily male (54% and 55%) and white (94% and 94%). The number of cases of IE increased from 190 in 2013 to 430 in 2016 (R2=0.9877). The number of IE cases diagnosed as having a SUD increased from 30 (16% of all IE cases) in 2013 to 130 (30% of all IE cases) in 2016 (R2=0.7352 for the trend). This increase in cases corresponds to a 333% increase in the number of cases of IE with SUD.


Between 2014 and 2016, opioid overdose deaths in Kentucky rose from 24.7 to 33.5 per 100,000 population, a 35.6% increase. During a similar timeframe, the number of IE cases associated with SUD at our institution rose 333%. While it is possible that increased coding of substance use disorders factored into this dramatic increase, it appears that the number of IE cases associated with SUD is rising at a disproportionately rapid rate.

Craig A. Martin, PharmD, MBA1, Donna R. Burgess, RPh2, Katie L. Wallace, PharmD, BCPS2, Jeremy Vanhoose, PharmD, BCPS2, Sarah Cotner, PharmD, BCPS3 and David S. Burgess, PharmD, FCCP, FIDP4, (1)Pharmacy Practice and Science, University of Kentucky, College of Pharmacy, Lexington, KY, (2)University of Kentucky HealthCare, Lexington, KY, (3)Pharmacy, University of Kentucky HealthCare, Lexington, KY, (4)University of Kentucky College of Pharmacy, Lexington, KY


C. A. Martin, None

D. R. Burgess, None

K. L. Wallace, None

J. Vanhoose, None

S. Cotner, None

D. S. Burgess, None

Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.