2314. Invasive Haemophilus influenzae Infections in Children: A Ten Year Study
Session: Poster Abstract Session: Pediatric Bacterial Infections
Saturday, October 6, 2018
Room: S Poster Hall
Posters
  • Final H. flu Poster ID Week 2018 10 2 2018-FINAL.pdf (385.2 kB)
  • Background: The rate of Haemophilus influenzae type b (HIB) infections has decreased dramatically since the use of HIB vaccines in infants and children. The current prevalence of invasive HIB infections and those due to non-type b H. influenzae is not fully known. The objective was to describe the cases of all invasive H. influenzae infections and describe the spectrum and severity of clinical disease.

    Methods: Retrospective study of all hospitalized patients with culture-proven invasive Haemophilus influenzae infections at Nationwide Children’s Hospital, Columbus, Ohio, from 2009 to 2018. The electronic health records were reviewed for pertinent demographic, clinical, laboratory data, and outcomes.

    Results: There were a total of 59 culture-proven H. influenzae infections of which 12 were excluded due to insufficient patient data. The remaining 47 patients (32 [68%] male; 30 [64%] white, 8 [17%] African-American) and their culture results are provided in Table:

    Haemophilus influenzae Infections in 47 Patients: Culture Results

    Type a

    N=1 (%)

    Type b

    N=3(%)

    Encapsulated non-b

    N=11(%)

    Not typeable

    N=30(%)

    Not typed

    N=2(%)

    Total

    N=47(%)

    <6 months

    0

    0

    0

    7(23)

    1(50)

    8(17)

    ≥6-12 months

    1(100)

    2(67)

    7(64)

    7(23)

    0

    17(36)

    >1-5 years

    0

    1(33)

    4(36)

    6(20)

    1(50)

    12(25)

    >5-8 years

    0

    0

    0

    8(26)

    0

    8(17)

    >8-17 years

    0

    0

    0

    0

    0

    0

    ≥18 years

    0

    0

    0

    2(6)

    0

    2(4)

    Blood only

    1(100)

    1(33)

    4(36)

    27(90)

    2(100)

    35(75)

    CSF only

    0

    1(33)

    0

    0

    0

    1(2)

    Both Blood and CSF

    0

    1(33)

    5(45)

    0

    0

    6(13)

    Both CSF and Peritoneal Fluid

    0

    0

    0

    1(3)

    0

    1(2)

    Both Blood and Synovial Fluid

    0

    0

    2(18)

    0

    0

    2(4)

    Both Blood and Eye Discharge

    0

    0

    0

    2(6)

    0

    2(4)

    Virus Coinfection

    1(100)

    3(100)

    3(27)

    14(46)

    1(50)

    22(47)

    Bacteria Coinfection

    0

    1(33)

    0

    5(16)

    2(100)

    8(17)

    Death

    0

    0

    0

    1(3)

    0

    1(2)

    There were 14 (30%) patients with pneumonia and bacteremia, 6 (13%) with meningitis and bacteremia, 2 (4%) with only meningitis, 1 (2%) with bacteremia/meningitis and septic hip, 2 (4%) septic arthritis with bacteremia, 1 (2%) with periorbital cellulitis and bacteremia, and 21 (45%) with only bacteremia. Of the 3 cases of H. influenzae type b, 2 had not been vaccinated while 1 received only 1 dose of HIB vaccine.

      Conclusion: Invasive H. influenzae infections were associated with substantial morbidity and a 2% case-fatality rate.

      Morvarid Elahi, MD, Nationwide Children Hospital, Columbus, OH, Pablo J. Sanchez, MD, FIDSA, FPIDS, Pediatrics, Divisions of Pediatric Infectious Diseases and Neonatology, Nationwide Children's Hospital - Ohio State University College of Medicine, Columbus, OH, Elham Alqudah, MD, Pediatrics, Nationwide Children's Hospital, Columbus, OH and Stella Antonara, PhD, Department of Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH

      Disclosures:

      M. Elahi, None

      P. J. Sanchez, None

      E. Alqudah, None

      S. Antonara, None

      Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.