Methods: We performed a case control study at Siriraj hospital, the biggest tertiary care hospital in Thailand, to determine the clinical difference and treatment outcome of this infection between HIV-infected and non-HIV infected individuals.
Results: From January 2012 to December 2017, there were twenty-one patients diagnosed with Mycobacterium haemophilum infections. Eight of them were HIV infected. Rest of the patients were non-HIV immunocompromised which SLE was the most common comorbidities (autoimmune diseases 6 patients, anti-IFN gamma auto Ab 2 patients, kidney transplant recipients 2 patients, diabetes mellitus 2 patients and nephrotic syndrome 1 patient). Most common clinical manifestation was cutaneous involvement (13 patients, 61.9%). The result revealed that HIV infected patients were much younger in comparison with non-HIV infected patients (Mean age 39 +/- 10 VS 52 +/-14 years; p-value 0.025). Disseminated infection was more common in HIV-infected patients (37.5% VS 15.4%, p-value 0.325) and three of eight HIV-infected patients (37.5%) had central nervous system involvement whereas none of non-HIV infected patients had it (p-value 0.042). The prognosis was slightly worse in HIV infected individuals (Unfavourable prognosis 27.5% in HIV infected VS 15.4% in non-HIV infected patients; p-value 0.325).
Conclusion: HIV infection is the most common immunocompromised condition related with Mycobacterium haemophilum infection. Central nervous system involvement is more common in HIV-infected patients.
S. Foongladda, None
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