2268. Clinical Difference of Mycobacterium haemophilum Infections between HIV and Non-HIV Infected Patients
Session: Poster Abstract Session: HIV: Opportunistic Infections and other Infectious Complications
Saturday, October 6, 2018
Room: S Poster Hall
Posters
  • ภาพหน้าจอ (132).png (1.2 MB)
  • Background: Mycobaterium haemophilum has emerged as one of nontuberculous mycobacteria which caused localized and disseminated infections in immunocompromised patients. Infections caused by this pathogen were rarely diagnosed and reported because it can grow only in heme supplemented culture media.

    Methods: We performed a case control study at Siriraj hospital, the biggest tertiary care hospital in Thailand, to determine the clinical difference and treatment outcome of this infection between HIV-infected and non-HIV infected individuals.

    Results: From January 2012 to December 2017, there were twenty-one patients diagnosed with Mycobacterium haemophilum infections. Eight of them were HIV infected. Rest of the patients were non-HIV immunocompromised which SLE was the most common comorbidities (autoimmune diseases 6 patients, anti-IFN gamma auto Ab 2 patients, kidney transplant recipients 2 patients, diabetes mellitus 2 patients and nephrotic syndrome 1 patient). Most common clinical manifestation was cutaneous involvement (13 patients, 61.9%). The result revealed that HIV infected patients were much younger in comparison with non-HIV infected patients (Mean age 39 +/- 10 VS 52 +/-14 years; p-value 0.025). Disseminated infection was more common in HIV-infected patients (37.5% VS 15.4%, p-value 0.325) and three of eight HIV-infected patients (37.5%) had central nervous system involvement whereas none of non-HIV infected patients had it (p-value 0.042). The prognosis was slightly worse in HIV infected individuals (Unfavourable prognosis 27.5% in HIV infected VS 15.4% in non-HIV infected patients; p-value 0.325).

    Conclusion: HIV infection is the most common immunocompromised condition related with Mycobacterium haemophilum infection. Central nervous system involvement is more common in HIV-infected patients.

    Pornboonya Nookeu, MD, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Pakpoom Phoompoung, MD, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand and Suporn Foongladda, DVM, PhD, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand

    Disclosures:

    P. Nookeu, None

    P. Phoompoung, None

    S. Foongladda, None

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