2127. The role of prophylactic antibiotics for reducing infections following knee arthroscopy
Session: Poster Abstract Session: Healthcare Epidemiology: Surgical Site Infections
Saturday, October 6, 2018
Room: S Poster Hall
Posters
  • ID week poster.pdf (266.8 kB)
  • Background: Surgical site infections (SSI) following arthroscopy are associated with considerable morbidity. Whether antibiotic prophylaxis can reduce the risk of SSI following knee arthroscopy is unclear.

    Methods: We undertook a meta-analysis of studies comparing incidence of SSI in patients receiving antibiotic prophylaxis versus no antibiotics before undergoing knee arthroscopy. We searched multiple computerized databases; data were pooled using a random effects model. We excluded knee arthroscopy studies for which the distribution of patients receiving antibiotics versus no antibiotics was unavailable. CDC definitions for SSI were used to determine incidence of infection.

    Results: Five retrospective studies including 47548 patients met inclusion criteria; none were randomized trials. The risk of SSI in the prophylactic antibiotic group was 0.38% and in the no antibiotic group was 0.37% (pooled OR 0.99, 95% CI 0.69-1.42). There was no statistical heterogeneity.

    Conclusion: The evidence to date, which is limited to retrospective studies, suggests no difference in SSI incidence with and without antibiotic prophylaxis for knee arthroscopies. Prospective studies are required to further evaluate this finding. Future research should evaluate whether antibiotic prophylaxis prevents SSI in other joint arthroscopy procedures, such as shoulder arthroscopy.

    Nasia Safdar, MD, PhD1,2, Catherine Shaughnessy, BS1, Jackson Musuuza, MBBS, MPH, PhD1,2 and Aurora Pop-Vicas, MD, MPH1, (1)University of Wisconsin, Madison, WI, (2)William S Middleton Memorial Veterans Hospital, Madison, WI

    Disclosures:

    N. Safdar, None

    C. Shaughnessy, None

    J. Musuuza, None

    A. Pop-Vicas, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.