there is limited knowledge of related morbidity. The purpose of this study was to describe the temporal,
geographic and clinical trends and characteristics of infective endocarditis associated with IDD (IDD-IE)
and to identify opportunities for better-quality care of people with IDD.
Methods: We reviewed charts for all admissions coded for both IE and drug use disorders at the
University of Virginia Medical Center (UVA) from January 2000 to July 2016. A random sample of 30
admissions coded for IE per year were reviewed to evaluate temporal trends in the proportion of IDD
associated IE cases.
Results: There were a total of 76 patients with IDD-IE during the study period, with a seven fold increase
in cases of IDD-IE from the early 2000s to 2016. The proportion of IE that was IDD-associated increased
by nearly 10% each year (prevalence ratio of IDD per year: 1.09, 95% CI: 1.05-1.14). Patients with IDDIE
had longer hospital stays [median days (interquartile range); IDD-IE, 17 (10-29); non-IDD-IE, 10 (6-
18); p-value = 0.001] with almost twice the cost of admission as those without IDD [median (interquartile
range); IDD-IE, $47,899 ($24,578-78,144); non-IDD-IE, $26,460 ($10,220-60,059); p-value = 0.001]. In
52% of cases there was no documentation of any discussion regarding addiction treatment.
Conclusion: IDD-IE cases are increasing in Virginia leading to higher morbidity and health care costs.
IDD-IE may provide an opportunity for the delivery of IDD treatment, counseling, and harm reduction
M. W. Scheld, None
R. Dillingham, None