2234. Implementing a Co-located HCV Clinic within an HIV Clinic: Four Year Experience
Session: Poster Abstract Session: HIV and Viral Hepatitis Co-Infection
Saturday, October 6, 2018
Room: S Poster Hall
  • HCV care model_POSTER IDWEEK2018 FINAL 9.26.2018[1].pdf (351.0 kB)
  • Background:

    Of the 1.2 M persons living with HIV in the United States, about 25% are co-infected with HCV. Even with the availability of highly effective direct antiviral agents (DAAs), the goal of HCV elimination requires improvements to the HCV treatment cascade, especially linkage to and initiation of treatment in underserved populations. We have implemented a co-located HCV clinic within our HIV clinic to circumvent barriers to HCV treatment.


    Between 3/1/2012 to 4/30/2017, all co-infected patients with chronic HCV infection (defined as positive HCV PCR) at Nathan Smith Clinic (HIV Clinic in New Haven, CT) were referred for consultation to the HCV co-infection clinic. This clinic was staffed by 3 physicians (additional HCV training), 1 physician assistant, 1 registered nurse and had access to a specialty pharmacy. Regular team meetings were held to review progress and treatment outcomes of patients who were initiated on DAAs. Relevant demographic, HIV and HCV parameters and clinic process data were abstracted and analyzed.


    Of the 174 total co-infected patients, 85% were born between 1946-1964; 66% were males and 56% were African Americans. Comorbidities included: cirrhosis (67%); mental health problems (61%); active alcohol (31%); active substance use (56%). The majority (n= 109, 63%) had HCV genotype 1. In terms of treatment cascade: 157 (90%) were referred to DAA prescriber, 140 (80%) were linked to DAA prescriber, and 102 (59%) started DAA therapy. Of the patients who started treatment, 84 (82%) had documented SVR12, 1 (1%) failed, 4 (4%) were awaiting SVR12 documentation, 7(7%) were on therapy, 4(4%) stopped therapy early, and 2 (2%) were lost to follow up. There were no re-infections. After initial uptake in referrals and treatment initiation, a plateau was reached.


    Establishing a co-located HCV clinic within an HIV clinic has been successful in facilitating pre-treatment evaluation with overall SVR achieved in 48% of co-infected patients which compares favorably to published national HCV treatment cascades in mono-infected patients. Additional patient and provider barriers to completing clinic-wide HCV elimination are being analyzed. New approaches for promoting engagement in care are needed.

    Merceditas Villanueva, MD1, Christina Rizk, MSc.2, Bethel Shiferaw, MD3, Onyema Ogbuagu, MD, FACP4, Maricar Malinis, MD, FACP, FIDSA5 and Janet Miceli, MPH3, (1)Medicine, Yale University, New Haven, CT, (2)AIDS Program, Yale University School of Medicine, New Haven, CT, (3)Yale University School of Medicine, New Haven, CT, (4)Department of Medicine, Section of Infectious Disease, Yale University School of Medicine, New Haven, CT, (5)Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT


    M. Villanueva, None

    C. Rizk, None

    B. Shiferaw, None

    O. Ogbuagu, None

    M. Malinis, None

    J. Miceli, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 3rd with the exception of research findings presented at the IDWeek press conferences.