41. Comparative clinical outcomes of candidemia associated hospitalizations between males and females: a population-based study
Session: Posters in the Park: Posters in the Park
Wednesday, October 3, 2018: 5:30 PM
Room: N Hall D Opening Reception and Posters in the Park Area
Background: Candida species are one of the most common causes of invasive fungal infections and are associated with significant morbidity and mortality. Although mortality rates have decreased over time, contemporary evaluations of outcomes and sex differences have not been assessed. We aimed to examine the differences in important clinical outcomes of candidemia associated hospitalizations between males and females in the United States

Methods: We used the 2014 National Inpatient Sample database to identify candidemia associated hospitalizations amongst adult patients aged 18 years and older (112.5 in the International Classification of Diseases 9th revision) in the United States. Patient demographic and clinical characteristics were described. Linear and logistic regression models were constructed for outcomes of death, length of stay (LOS) and hospitalization charges between males and females using STATA 14.2 (College Stn, TX).

Results: There were a total of 2,433 hospitalizations with a diagnosis of candidemia of mean age 56.8 years (SD 21.1) Of these, 1,214 were in females (49.9%) and 1,219 were in males (50.1%) and both groups had similar age distributions. A total of 463 patients died during the hospitalization (19%). Females had an odds ratio for dying of 0.84 (95% CI 0.69 to 1.03) compared to males. Mean LOS was 1.31 days lower (95% CI -3.47 to 0.85) for females compared to males but was not significant. Mean total charges were $32,030 lower for females (95% CI -$63,951.58 to -$109.65, p=0.049) compared to males.

Conclusion: In our population-based study, candidemia was associated with significant mortality but with the exception of hospitalization charges, outcomes of death and LOS did not differ between males and females. Given the associated mortality of invasive candidemia, further studies of prevention and therapeutics are required.

Kwadwo Mponponsuo, MD, Medicine, University of Calgary, Calgary, AB, Canada, Vikram Lekhi, M.D., Surgery, University of Calgary, Calgary, AB, Canada, Elissa Rennert-May, MD, Division of Infectious Diseases, University of Alberta, Edmonton, AB, Canada, Michael Parkins, MD, Department of Medicine; Division of Microbiology & Infectious Diseases, University of Calgary, Calgary, AB, Canada, Christopher Goss, MD, MSc, Department of Medicine & Pediatrics, University of Washington, Seattle, WA and Ranjani Somayaji, M.D., Department of Medicine;, University of Calgary and Alberta Health Services - Calgary zone, Calgary, AB, Canada

Disclosures:

K. Mponponsuo, None

V. Lekhi, None

E. Rennert-May, None

M. Parkins, None

C. Goss, None

R. Somayaji, None

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